Non-hydrolytic functions of acetylcholinesterase
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چکیده
منابع مشابه
Hydrolytic and nonenzymatic functions of acetylcholinesterase comodulate hemopoietic stress responses.
Glucocorticoid-initiated granulocytosis, excessive proliferation of granulocytes, persists after cortisol levels are lowered, suggesting the involvement of additional stress mediator(s). In this study, we report that the stress-induced acetylcholinesterase variant, AChE-R, and its cleavable, cell-penetrating C-terminal peptide, ARP, facilitate granulocytosis. In postdelivery patients, AChE-R-ex...
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24 Schalk, I., Ehret-Sabatier, I,., Houet, F., Goeldner, M. and Hirth, C. (1994) Eur. J. Hiochem. 219, 155-159 2.5 Harel, M., Sussman, J. I,., Krejci, E.> Hon, S., Chanal. P., Massoulie, J. and Silman. I. (1992) Proc. Natl. Acad. Sci. LJSA. 89, 108271083 1 26 Eichler, J.. Anselmet, A,, Sussman, J. I,.. Massoulie, J. and Silman, 1. (1994) Mol. Pharmacol. 45, 335-340 27 Kadic, Z.. I’ickering, N.,...
متن کاملAcetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology.
The synaptic enzyme acetylcholinesterase (AChE) terminates transmission at cholinergic synapses by rapidly hydrolysing acetylcholine. It is anchored within the synaptic cleft by a highly specialized anchoring device in which catalytic subunit tetramers assemble around a polyproline II helix. AChE is the target of nerve agents, insecticides and therapeutic drugs, in particular the first generati...
متن کاملCholinergic and non-cholinergic functions of two acetylcholinesterase genes revealed by gene-silencing in Tribolium castaneum
We compared biological functions of two acetylcholinesterase genes (TcAce1 and TcAce2) in Tribolium castaneum, a globally distributed major pest of stored grain products and an emerging model organism, by using RNA interference. Although both genes expressed at all developmental stages and mainly in the brain, the transcript level of TcAce1 was 1.2- to 8.7-fold higher than that of TcAce2, depen...
متن کاملThe Power of Non-Hydrolytic Sol-Gel Chemistry: A Review
This review is devoted to non-hydrolytic sol-gel chemistry. During the last 25 years, non-hydrolytic sol-gel (NHSG) techniques were found to be attractive and versatile methods for the preparation of oxide materials. Compared to conventional hydrolytic approaches, the NHSG route allows reaction control at the atomic scale resulting in homogeneous and well defined products. Due to these features...
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ژورنال
عنوان ژورنال: FEBS Journal
سال: 2008
ISSN: 1742-464X
DOI: 10.1111/j.1742-4658.2007.06235.x